Male Infertility Conditions

Male infertility means not being able to father children. Infertility is the inability of a sexually active, non-contracepting couple to achieve spontaneous pregnancy in one year. If the cause of the fertility problem is found in the man, this is male infertility. In over a third of infertility cases, the problem is with the man. This is most often due to problems with his sperm production or with sperm delivery.

What Happens Under Normal Conditions?

The man’s body makes tiny cells called sperm. During sex, ejaculation normally delivers the sperm into the woman’s body.

The male reproductive system makes, stores, and transports sperm. Chemicals in man’s body called hormones control this. Sperm and male sex hormone (testosterone) are made in the 2 testicles, located in scrotum, the sac of skin below the penis. When the sperm leave the testicles, they go into a tube behind each testicle, called the epididymis.

Just before ejaculation, the sperm go from the epididymis into another set of tubes, called vas deferens. Each vas deferens traverses the scrotum, enters the abdomen and joins the ejaculatory duct and seminal vesicle behind the bladder in the pelvis. When ejaculation occur, the sperm mix with fluid from the prostate and seminal vesicles. This forms semen. Semen then travels through the urethra and out of the penis.

Male fertility depends on man’s body making normal sperm and delivering them. The sperm go into the female partner’s vagina. The sperm travel through the woman’s cervix into her uterus to her fallopian tubes. There, if a sperm and egg meet, fertilization happens.

The system only works when genes, hormone levels and environmental conditions are right.

What are the common causes of male infertility?

Making mature, healthy sperm that can travel depends on many things. Problems can stop cells from growing into sperm. Problems can keep the sperm from reaching the egg. Even the temperature of the scrotum may affect fertility. The main causes of male infertility:

  • Sperm Disorders. The most common problems are with making and growing sperm.
  • Sperms may not grow fully
  • be oddly shaped
  • not move the right way
  • be made in very low numbers (oligospermia)
  • not be made at all (azoospermia)

Sperm problems can be from traits a man is born with (genetic diseases). Lifestyle choices can lower sperm numbers. Smoking, drinking alcohol, and taking certain medications can lower sperm numbers. Other causes of low sperm numbers include long-term sickness (such as kidney failure), childhood infections (such as mumps), and chromosome or hormone problems (such as low testosterone).

Damage to the reproductive system can cause low or no sperm. About 4 out of every 10 men with total lack of sperm (azoospermia) have an obstruction (blockage) within the tubes the sperm travel through. A birth defect or a problem such as an infection can cause a blockage.

Other causes of Male Infertility are:

  • Varicoceles Varicoceles are swollen veins in the scrotum. They’re found in 16 out of 100 of all men, but are more common in infertile men (40 out of 100). They harm sperm growth by blocking proper blood drainage. For more information please refer to the Varicoceles information page.
  • Retrograde Ejaculation. Retrograde ejaculation is when semen goes backwards in the body into the bladder instead of out the penis. This happens when nerves and muscles in yourman’s bladder don’t close during orgasm (climax). Semen may have normal sperm, but the semen is not released from the penis, so it cannot reach the vagina.
  • Immunonologic Infertility. Sometimes a man’s body makes antibodies that attack his own sperm. Antibodies are most often made because of injury, surgery or infection. They keep sperm from moving and working normally.
  • Obstruction. Sometimes the tubes through which sperm travel can be blocked. Repeated infections, surgery (such as vasectomy), swelling or developmental defects can cause blockage. 
  • Hormones. Very low hormone levels cause poor sperm growth.
  • Medication. Common medications that can change sperm production, function and delivery are medications for arthritis, depression, digestive problems, anxiety or depression, infections, high blood pressure, cancer. 

What are the common diagnostic tests?

Causes of male fertility can be hard to diagnose. The problems are most often with sperm production or delivery. Diagnosis starts with a full history and physical exam. Other commonly utilized diagnostic tests are:

  • Semen analysis
  • Hormonal Profile
  • Scrotal and testicular ultrasound
  • Testicular Biopsy

What treatment options are available?

Treatment depends on what’s causing infertility. Many problems can be fixed with drugs or surgery. This would allow conception through normal sex. In certain cases with no response to medical treatment or when surgery is not feasible (unknown causes of male infertility), sperm harvest from the testis and assisted reproduction techniques (IVF) may be required.

Frequently Asked Questions on Male Infertility

  • What health problems can cause male infertility?

    Many health problems–from kidney disease to testicular cancer–can result in male infertility. “Whole-body” health problems and metabolic disorders, and ordinary fevers and infections can harm sperm growth. Diseases passed through sex can lead to blocks and scars in the reproductive tract.

    Genetic health problems, such as cystic fibrosis can cause the vas deferens or seminal vesicles to be absent leading to no sperm in the semen. Many illnesses can cause infertility. It’s important that you and your partner tell your family and personal health histories to your health care provider.

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